Media mention: ‘Membrane Technology Significantly Intensifies Gene Therapy Manufacturing’
May 19, 2025
Where: Chemical Engineering Progress, “Catalyzing Commercialization: Membrane Technology Significantly Intensifies Gene Therapy Manufacturing”
Who: Penn State researchers in collaboration with the University of Arkansas and Spark Therapeutics, through the U.S. National Science Foundation-funded Membrane Applications Science and Technology (MAST) Center
What: A recent article in Chemical Engineering Progress, the flagship magazine of the American Institute of Chemical Engineers, highlights collaborative research led by the MAST Center, including Penn State researchers, on a novel single-pass tangential flow filtration system that intensifies the production of adeno-associated viral vectors used in gene therapy. The innovative process eliminates the need for recirculation, reduces shear stress on the product and significantly improves purification efficiency — marking a key advancement toward continuous and cost-effective adeno-associated viruses manufacturing.
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